We are excited to have published a collaborative paper with Chris French's lab at Brigham and Women's Hospital in the journal Cancer Research! We identify EZH2, a chromatin regulator that epigenetically silences genes, as a novel vulnerability in NUT carcinoma, that EZH2 suppression of tumor suppressor genes acts in parallel to the activation of oncogenes by the fusion oncoprotein BRD4-NUT, and that combined treatment of mouse models of NUT carcinoma with both an EZH2 inhibitor and a BET inhibitor potently blocks tumor growth and prolongs animal survival. Congratulations to Cate, Chris, and Quan for their contributions to the success of this project! Click here for full text and also see the spotlight commentary on the paper in Cancer Research.
The Eagen Lab is not deterred by the hot Texas weather! We began with BBQ for lunch at Truth...
...followed by some escape room fun! Some of us made it out!
Ivo Yonchev joins us from the University of Sheffield as a postdoctoral associate! Welcome to the Eagen Lab!
Yi-Hung Chen joins us as a graduate student in the Development, Disease Models & Therapeutics Graduate Program at Baylor College of Medicine! Welcome to the Eagen Lab!
The lab enjoyed learning about all the exciting science during the 2023 Department of Molecular and Cellular Biology Retreat at the Houston Zoom!
John Collette joins us as a research associate from a neighboring lab at Baylor College of Medicine. Welcome to the Eagen Lab!
The lab had a fun time at the 2022 Department of Molecular and Cellular Biology Halloween Party. The lab took 3rd place in the costume contest and Cate won 1st place in the pie baking competition!
Chris Ponne and Quan Le joins us as a research technicians! Chris is from Kenyon College and Quan joins us from Yale University. Welcome to the Eagen Lab!
Cate Hawkins joins us from the University of Dayton as a research technician! Welcome to the Eagen Lab!
Thrilled to contribute a News & Views article on two new exciting papers in Nature Genetics! Highlights includes how BET proteins, BRD4 in particular, contribute to cohesin-dependent chromatin looping and cohesin-independent genome compartmentalization. Click here for full text.
The lab has completed its move to Houston, is unpacking, and opens its doors at Baylor College of Medicine! We are recruiting for multiple positions at all levels - postdoctoral fellows, graduate students, computational biologist, and research technicians & associates - so please email Kyle if you're interested in joining us!
We are thrilled to announce that the Eagen Lab will be moving to Baylor College of Medicine on November 1, 2021! We will be joining the Department of Molecular and Cellular Biology and will also be affiliated with the Center for Precision Environmental Health, the Stem Cells and Regenerative Medicine Center, and the Center for Cell and Gene Therapy. We are recruiting for multiple positions at all levels, so please contact Kyle if you're interested in joining us!
Kyle is honored to be awarded a generous First-Time, Tenure-Track Faculty Award from the Cancer Prevention & Research Institute of Texas (CPRIT). This CPRIT grant will allow the lab to pursue high-risk, high-reward projects at the interface of nuclear organization and cancer. Click here for the press release from CPRIT.
Congratulations to Celeste on receiving an NSF Graduate Research Fellowship!
Our review with collaborator Chris French at Brigham and Women's Hospital presenting a mechanistic model for how fusion with NUT supercharges BRD4's function as a transcriptional coactivator, including our recent discovery of a novel nuclear subcompartment, is published in Oncogene! Click here for full text.