Eagen Lab, Spring 2024
Lab Members
Kyle Eagen, Ph.D.
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Kyle is an Assistant Professor in the Department of Molecular and Cellular Biology at Baylor College of Medicine. He received his B.S. degree in Biological Sciences with a concentration in Biochemistry from Cornell University. He obtained his Ph.D. in Biophysics from Stanford University where he worked with Roger Kornberg studying chromatin and chromosome structure. After completing graduate training, Kyle began his independent career in 2017 as the inaugural Feinberg Fellow at the Northwestern University Feinberg School of Medicine. In 2021 he joined the faculty of Baylor College of Medicine. He is a recipient of an NIH Director's Early Independence Award, a CPRIT Scholar in Cancer Research Award, a Sontag Foundation Distinguished Scientist Award, and an Alex's Lemonade Stand Foundation for Childhood Cancer R Accelerated Award.
Ivo received his B.Sc. in Biochemistry from the University of Sheffield, where he used X-ray crystallography to investigate the use of triazole-phosphonate inhibitors as novel antimicrobial drugs against Mycobacteria in the lab of David Rice. He stayed in Sheffield for his Ph.D. degree and a short postdoctoral position, in the labs of Stuart Wilson and Ian Sudbery, where he applied next-generation sequencing techniques to study the roles of the nuclear proteins hnRNPU and hnRNPUL1 in regulating gene expression. His scientific interests lie in the cellular roles of non-coding RNAs, chromatin biology, and RNA polymerase II transcription. He is currently exploiting chromatin regulation by fusion oncoproteins to investigate how chromatin architecture influences gene expression.
Yi-Hung is a Graduate Student in the Development, Disease Models & Therapeutics Graduate Program at Baylor College of Medicine. She received her B.S. degree in Pharmacy from Taipei Medical University and her M.S. degree in Pharmacology from National Yang Ming Chiao Tung University in Taiwan where she studied the involvement of RNA m6A modification in EGFR-TKIs resistant lung adenocarcinoma. Yi-Hung joined the University of Houston as a research assistant in Tai-Yen Chen’s lab. Her work focused on establishing a mEos4B-CTR1 knock-in hESCs cell line using CRISPR-Cas9 technology. Before joining Baylor College of Medicine, Yi-Hung was a research assistant at UTHealth where she worked for Dung-Fang Lee studying hereditary retinoblastoma in patient derived iPSC models.
Anna is a graduate student in the Genetics & Genomics Graduate Program at Baylor College of Medicine. She received her B.Sc. in Advanced Zoology and Biotechnology from Women’s Christian College in India and her M.Res. in Medical Genetics from Newcastle University in the UK. During her Master’s, Anna worked in the lab of Dr. Konstantinos Stellos where she studied the effect of the RNA editing enzyme ADAR1 on the metabolism of the long non-coding RNA NEAT1 and its implications in cardiovascular disease. Prior to joining Baylor College of Medicine, Anna was a research assistant in Dr. Blaine Bartholomew’s lab where she worked on understanding the role of chromatin remodeling complexes in development and disease.
Adela is a graduate student in the Genetics & Genomics Graduate Program at Baylor College of Medicine. She received a Bachelor of Science in Molecular Genetics from the University of Rochester, where her research focused on the role of the Nkx2.3 transcription factor in the regeneration of sublingual salivary glands. Prior to joining Baylor College of Medicine, Adela was a lab technician in Dr. Douglas Anderson's lab at the University of Rochester Medical Center. In this role, she worked on validating an innovative technology involving ribozyme-mediated RNA cleavage and the subsequent trans-ligation of two RNA fragments in E. coli.
John is a Research Associate at Baylor College of Medicine. John received his B.S. degree in Biochemistry from Texas Tech University and his Ph.D. degree in Biochemistry from the University of North Carolina at Chapel Hill where he worked for Ann Erickson studying lysosomal enzyme trafficking. John continued his training as a postdoctoral fellow in the laboratory of Sandra Lemmon at the University of Miami studying clathrin-mediated endocytosis in Saccharomyces cerevisiae. John returned to Texas upon joining the lab of Michael Lorenz at UTHealth to study virulence traits of the pathogenic fungus Candida albicans. Most recently, he worked with Richard Sifers at Baylor College of Medicine to study proteins and pathways involved in degradation of terminally-misfolded alpha-1-antitrypsin protein.
Krupa is a Bioinformatics Analyst in the Eagen Lab, Baylor College of Medicine. She has a Master of Science in Bioinformatics from Boston University, a post-graduate diploma in Bioinformatics from Mumbai University, and a Bachelor of Science in Microbiology. Through her diverse educational and professional experiences she has cultivated both wet lab and computational skills. She has expertise in NGS data analysis, including bulk RNA-seq, scRNA-seq, ChIP-seq, and metagenomics, and has extensively utilized a diverse array of bioinformatics tools. Her computational languages are Python, R, and Bash. Her interests lie in cancer genomics and metagenomics, and she is passionate about meaningfully to these dynamic and crucial areas of research.
In 2022, Cate joined Baylor College of Medicine as a Research Technician in the Department of Molecular and Cellular Biology. She graduated from the University of Dayton in 2022 where she received her bachelor’s degree in Biochemistry with a minor in English. Throughout her undergraduate career, she investigated the use of boron dipyrromethene dyes as potential photodynamic therapy agents in the lab of Shawn Swavey.
In 2022, Chris joined the Baylor College of Medicine as a Research Technician in the Department of Molecular and Cellular Biology. He graduated from Kenyon College in 2022 where he received his bachelor’s degree in Molecular Biology. During his undergraduate, he conducted research focusing on the crosstalk between the thyroid hormone pathway and aryl hydrocarbon receptor signaling in a tissue specific manner under the guidance of Wade Powell.
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Alumni
Northwestern University (2017-2021)
2017-2020
2017-2021 2019-2020 2019-2021 2020-2021 2020-2021 |
Haneen Ammouri, Research Technician
Celeste Rosencrance, Research Technician, Graduate Student Qi Yu, Bioinformatics Scientist Tiffany Ge, Graduate Student Jingxiao Zhang, Bioinformatics Scientist Grant Zimmerman, Research Technician |
Currently: Lab Manager, Vanqua Bio
Currently: Graduate Student, Northwestern University Currently: Staff, NIH Currently: Graduate Student, Northwestern University Currently: Bioinformatics Specialist, Qiagen Currently: Medical Student, Midwestern University |
Baylor College of Medicine (2021-Present)
2022-2024
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Quan Le, Research Technician
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We have openings for postdoctoral fellows, graduate students, and computational biologists interested in problems at the intersection of nuclear organization, chromosome biology, biochemistry, genomics, computational biology, pharmacology and human disease.
Interested applicants should email Kyle, including their CV and a brief description of their research interests.
Interested applicants should email Kyle, including their CV and a brief description of their research interests.