Eagen Lab at the Houston Rodeo, Spring 2025
Lab Members
Kyle Eagen, Ph.D.
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Kyle is an Assistant Professor in the Department of Molecular and Cellular Biology at Baylor College of Medicine. He received his B.S. degree in Biological Sciences with a concentration in Biochemistry from Cornell University. He obtained his Ph.D. in Biophysics from Stanford University where he worked with Roger Kornberg studying chromatin and chromosome structure. After completing graduate training, Kyle began his independent career in 2017 as the inaugural Feinberg Fellow at the Northwestern University Feinberg School of Medicine. In 2021 he joined the faculty of Baylor College of Medicine. He is a recipient of an NIH Director's Early Independence Award, a CPRIT Scholar in Cancer Research Award, a Sontag Foundation Distinguished Scientist Award, and an Alex's Lemonade Stand Foundation for Childhood Cancer R Accelerated Award.
Sara earned a B.S. from Bahauddin Zakariya University and an M.S. from Lahore University of Management Sciences (LUMS). During her master's she studied placental trophoblast stem cells and their polyploid, differentiated counterparts. Her work explored pathways that confer apoptosis resistance in polyploid cells and regulate trophoblast differentiation, including high-throughput inhibitor-library screens to identify novel regulators. She completed her Ph.D. in Biology at Florida State University, applying high-resolution fluorescence microscopy and chromosome conformation capture (Hi-C) to map chromatin organization and its relationship to replication timing across S phase. Her research interests lie in how chromatin architecture enables normal states such as polyploidy, and how mutations or rearrangements subvert these programs to drive disease such as cancer. Her current research investigates how fusion oncoproteins remodel chromatin and rewire gene expression in cancer.
Yi-Hung is a Graduate Student in the Development, Disease Models & Therapeutics Graduate Program at Baylor College of Medicine. She received her B.S. degree in Pharmacy from Taipei Medical University and her M.S. degree in Pharmacology from National Yang Ming Chiao Tung University in Taiwan where she studied the involvement of RNA m6A modification in EGFR-TKIs resistant lung adenocarcinoma. Yi-Hung joined the University of Houston as a research assistant in Tai-Yen Chen’s lab. Her work focused on establishing a mEos4B-CTR1 knock-in hESCs cell line using CRISPR-Cas9 technology. Before joining Baylor College of Medicine, Yi-Hung was a research assistant at UTHealth where she worked for Dung-Fang Lee studying hereditary retinoblastoma in patient derived iPSC models.
Adela is a graduate student in the Genetics & Genomics Graduate Program at Baylor College of Medicine. She received a Bachelor of Science in Molecular Genetics from the University of Rochester, where her research focused on the role of the Nkx2.3 transcription factor in the regeneration of sublingual salivary glands. Prior to joining Baylor College of Medicine, Adela was a lab technician in Dr. Douglas Anderson's lab at the University of Rochester Medical Center. In this role, she worked on validating an innovative technology involving ribozyme-mediated RNA cleavage and the subsequent trans-ligation of two RNA fragments in E. coli.
John is a Research Associate at Baylor College of Medicine. John received his B.S. degree in Biochemistry from Texas Tech University and his Ph.D. degree in Biochemistry from the University of North Carolina at Chapel Hill where he worked for Ann Erickson studying lysosomal enzyme trafficking. John continued his training as a postdoctoral fellow in the laboratory of Sandra Lemmon at the University of Miami studying clathrin-mediated endocytosis in Saccharomyces cerevisiae. John returned to Texas upon joining the lab of Michael Lorenz at UTHealth to study virulence traits of the pathogenic fungus Candida albicans. Most recently, he worked with Richard Sifers at Baylor College of Medicine to study proteins and pathways involved in degradation of terminally-misfolded alpha-1-antitrypsin protein.
Krupa is a Bioinformatics Analyst in the Eagen Lab, Baylor College of Medicine. She has a Master of Science in Bioinformatics from Boston University, a post-graduate diploma in Bioinformatics from Mumbai University, and a Bachelor of Science in Microbiology. Through her diverse educational and professional experiences she has cultivated both wet lab and computational skills. She has expertise in NGS data analysis, including bulk RNA-seq, scRNA-seq, ChIP-seq, and metagenomics, and has extensively utilized a diverse array of bioinformatics tools. Her computational languages are Python, R, and Bash. Her interests lie in cancer genomics and metagenomics, and she is passionate about meaningfully to these dynamic and crucial areas of research.
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Alumni
Northwestern University (2017-2021)
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Alumna/Alumnus
Haneen Ammouri Celeste Rosencrance Qi Yu Tiffany Ge Jingxiao Zhang Grant Zimmerman |
Position
Research Technician Research Technician, Graduate Student Bioinformatics Scientist Graduate Student Bioinformatics Scientist Research Technician |
Dates in Lab
2017-2020 2017-2021 2019-2020 2019-2021 2020-2021 2020-2021 |
Position after Leaving Lab
Lab Manager, Vanqua Bio Graduate Student, Northwestern University Staff, NIH Graduate Student, Northwestern University Bioinformatics Specialist, Qiagen Medical Student, Midwestern University |
Baylor College of Medicine (2021-Present)
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Alumna/Alumnus
Catherine Hawkins Christopher Ponne Ivo Yonchev |
Position
Research Technician Research Technician Postdoctoral Associate |
Dates in Lab
2022-2024 2022-2024 2023-2025 |
Position after Leaving Lab
Medical Student, Sam Houston State University Research Technician, Northwestern University Senior Scientist, AstraZeneca |
We have openings for postdoctoral fellows, graduate students, and computational biologists interested in problems at the intersection of nuclear organization, chromosome biology, epigenetics, genomics, pharmacology and fusion oncoprotein biochemistry.
Interested applicants should email Kyle, including their CV and a brief description of their research interests.
Interested applicants should email Kyle, including their CV and a brief description of their research interests.