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Rodeo 2025!

3/21/2025

 
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The lab had a great time at our annual spring outing to the Houston Rodeo!
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Lab Outing to Slick City Action Park!

9/23/2024

 
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Team bonding at Slick City Action Park! From thrilling slides to laughter-filled moments, our lab outing was a blast!

New NIH U01 Grant from NCI!

8/1/2024

 
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We truly appreciate the NIH / NCI for funding our U01 grant with long-time collaborator Dr. Christopher French on "Overcoming Limitations of BET Inhibition in NUT Carcinoma". This generous support will fund research projects to reveal how BRD4-NUT misregulates chromatin to drive tumorigenesis thereby providing insights into new therapies for NUT carcinoma. We are looking forward to exciting results from this project and are excited to by part of the NCI Targeting Fusion Oncoproteins in Childhood Cancers (TFCC) Network!

Welcome Shuvra!

7/15/2024

 
Shuvra Roy joins us from the CSIR-Institute of Genomics and Integrative Biology as a postdoctoral associate! Welcome to the Eagen Lab!

Congratulations, Cate!

5/10/2024

 
Congratulations to Cate as she starts medical school!

Houston Rodeo!

3/14/2024

 
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In what is becoming a lab tradition, the lab had a fantastic time at the Houston Rodeo! Feeling adventurous, John, Chris, and Ivo tried the Fruity Pebbles Shrimp Fried Rice in a pineapple bowl.
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Welcome Adela and Anna!

3/11/2024

 
Adela Yan and Anna Thommen join us as a graduate students in the Genetics & Genomics Program at Baylor College of Medicine!  Welcome to the Eagen Lab!

Welcome Krupa!

2/26/2024

 
Krupa Sampat joins us from Boston University as a bioinformatics analyst!  Welcome to the Eagen Lab!

Epigenetics Podcast!

1/11/2024

 
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Kyle was interviewed for the Epigenetics Podcast by Active Motif! Listen to the podcast to learn about his scientific journey, problems we are currently thinking about, and more here!

Cancer Research Paper Published!

12/1/2023

 
We are excited to have published a collaborative paper with Chris French's lab at Brigham and Women's Hospital in the journal Cancer Research! We identify EZH2, a chromatin regulator that epigenetically silences genes, as a novel vulnerability in NUT carcinoma, that EZH2 suppression of tumor suppressor genes acts in parallel to the activation of oncogenes by the fusion oncoprotein BRD4-NUT, and that combined treatment of mouse models of NUT carcinoma with both an EZH2 inhibitor and a BET inhibitor potently blocks tumor growth and prolongs animal survival. Congratulations to Cate, Chris, and Quan for their contributions to the success of this project! Click here for full text and also see the spotlight commentary on the paper in Cancer Research.

Congratulations, French Lab!

12/1/2023

 
Congratulations to the French Lab at Brigham and Women's Hospital and Harvard Medical School for their new paper "The BRD4–NUT Fusion Alone Drives Malignant Transformation of NUT Carcinoma"! We were happy to contribute to this story! Click here for full text.

Kyle receives Sontag Foundation Distinguished Scientist Award!

11/14/2023

 
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Kyle is grateful and thrilled to receive the Distinguished Scientist Award from The Sontag Foundation. This generous funding will allow the lab to expand into new research areas and determine how fusion oncoproteins that drive aggressive brain tumors alter chromosome 3D structure, nuclear organization, and transcriptional regulation. Read more about this exciting news from the Sontag Foundation news release and website.
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Lab Lunch!

8/3/2023

 
The team took a quick break from the lab for lunch at Winnie's in Midtown, Houston!
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New Lab Video!

7/11/2023

 
We had a great time filming a new video to highlight the lab's research! Check it out below.

Summer 2023 Lab Outing!

6/22/2023

 
The Eagen Lab is not deterred by the hot Texas weather! We began with BBQ for lunch at Truth...
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...followed by some escape room fun! Some of us made it out!
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How we do cell culture...

6/12/2023

 
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Welcome Ivo!

4/24/2023

 
Ivo Yonchev joins us from the University of Sheffield as a postdoctoral associate! Welcome to the Eagen Lab!

Welcome Yi-Hung!

4/18/2023

 
Yi-Hung Chen joins us as a graduate student in the Development, Disease Models & Therapeutics Graduate Program at Baylor College of Medicine!  Welcome to the Eagen Lab!

MCB Retreat!

3/23/2023

 
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The lab enjoyed learning about all the exciting science during the 2023 Department of Molecular and Cellular Biology Retreat at the Houston Zoom!

Rodeo Houston!

3/1/2023

 
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The lab enjoyed some nice March weather and had a great time at Rodeo Houston!

Kyle receives ALSF R Accelerated Award!

1/16/2023

 
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Kyle is grateful to receive an R Accelerated Award from the Alex's Lemonade Stand Foundation (ALSF) for Childhood Cancer. This generous funding will support research projects in the lab about how chromosome 3D structure is reprogrammed in cancer and how to intervene in this reprogramming for therapeutic purposes. Read more about the project on the ALSF website and blog.

Welcome John!

11/1/2022

 
John Collette joins us as a research associate from a neighboring lab at Baylor College of Medicine. Welcome to the Eagen Lab!

Happy Halloween!

10/28/2022

 
The lab had a fun time at the 2022 Department of Molecular and Cellular Biology Halloween Party. The lab took 3rd place in the costume contest and Cate won 1st place in the pie baking competition!
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BBQ!

9/16/2022

 
Enjoying the fantastic food scene in Houston, the lab had a great time at Truth BBQ!
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Welcome Chris & Quan!

6/6/2022

 
Chris Ponne and Quan Le joins us as a research technicians! Chris is from Kenyon College and Quan joins us from Yale University. Welcome to the Eagen Lab!
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EAGEN LAB
Baylor College of Medicine
Department of Molecular and Cellular Biology

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